Collaboration with University of New Hampshire, USA

The Coordinator of NBU Bioinformatics Facility, Dr. Arnab Sen has set up a long term collaboration with Prof. Louis S. Tisa, Department of Microbiology, University of New Hampshire, USA. He along with Dr. Loius S. Tisa has been working towards the complete genome sequencing of five Frankia strains collected from different parts of the world. NBU Bioinformatics Facility is the only Bioinformatics centre in India to launch a genome sequencing project.


Frankia genome sequencing project

Frankia sp. is a nitrogen fixing actinomycete, entering into symbiotic association with a number of woody dicotyledonous trees and shrubs in a symbiosis known as "actinorhizal". Frankia in association with these plants can fix nitrogen within the root nodules of these plants. Since Frankia strains fix nitrogen, actinorhizal plants grow well on depleted soils. Actinorhizal plants are potential sources of biomass for energy generation and carbon sequestration, and have been used for remediation of marginal soils. Frankia form the major nitrogen-fixing symbioses in the temperate forests of the world and have immense unexploited potential to contribute to energy production, waste remediation, and cleanup missions. The genome sequencing project of five Frankia strains is being funded by DOE Joint Genome Institute (United States Department of Energy). Most of the sequence analysis generated from this project will be done in the NBU Bioinformatics Facility. The Frankia strains selected for sequencing represent isolates from diverse biogeographical environments as well as different climatic zones. They come from four continents (North America, South America, Africa, and Asia) and diverse habitats, including dry soils with high salinity levels, steppe-like plains, and forests in the mountainous regions. One of the five Frankia strains that has been selected for sequencing purposes was isolated by Dr. Sen’s group from the Mirik hills of North Bengal. This particular strain enters into symbiotic association with alder (Alnus) plants. This strain is a representative of one foremost lineage (Cluster 1 phylogroup) that has a restricted host range. Four other strains (EuI1c, BCU110501, R43, and BMG5.12) are members of one of the major lineages (Cluster 3 phylogroup) within the genus and have a broad host range and distinctive characteristics including diverse metal tolerance. DNA sequence information derived from this project will provide workers and scientists with enormous amount of information and pave the way for newer dimensions in understanding Frankia biology. The data obtained from the project is also expected to throw light on the host-Frankia symbiosis existing under different climatic and environmental conditions.


Collaboration with University of Lyon, France

We are in a process of developing a collaboration with Prof. Philippe Normand, University of Lyon, France. Presently we are studying the molecular evolution of secretory proteins in Frankia and related genera.



Collaboration with University of Calcutta

Both the coordinators have established a scientific collaboration with Prof. Subhasish Mukherjee of Calcutta University





Collaboration with University of Tunis, Tunisia

Recently the Coordinator Prof. Arnab Sen has established research collaboration with Prof. Maher Gtari of University of Tunis, Tunisia and published several research papers in reputed International Journals. What's more, they have also got a collaborative research project (Indo-Tunis project) on Actinorhizal plants and their microsymbioants.

genome Genome Projects
Home | Bioinformatics | About Us | Research | Publication | Coordinators | Collaboration | Contact Us